![](/sites/default/files/styles/faculty_photo/public/images/content/faculty/Payel%20Datta.jpg?itok=myNVpKWp)
生物制造和生物加工项目主任
Assistant Professor
Focus: Mammalian Cell/Biologics
Contact Information
518-694-7483
Payel.datta@sitecata.com
Speaker Request
Dr. Payel Datta earned her Ph.D. 在伦斯勒理工学院(RPI, NY)获得生命科学博士学位.D. 工作重点是“代谢工程哺乳动物细胞生产增值生物分子”。. 她在奥尔巴尼医学院的博士后工作重点是开发和利用基于3D细胞的分析. Dr. Datta在肝素应用研究中心(初创行业- rpi)的工作, NY) focused on process development, scale-up, and tech transfer of value-added products (e.g.、酶、小分子、抗凝血药物肝素、益生菌). 此外,她的研究重点是药物疗效和毒性研究. Dr. 达塔与人合著了《全球十大赌博靠谱的平台》中的一章, numerous publications in peer-reviewed journals, presented work at conferences, and authored technical documents. Dr. Datta非常积极地利用她的专业知识和教学知识, research, and workforce development.
Education
- Ph.D.,生物学,伦斯勒理工学院,特洛伊,纽约,2013
Academic Courses Taught at ACPHS (2021-Present)
- BIO 331/631G Mammalian Cell Culture
- BIO 348/648G Microbial Fermentation
- BIO 675G生物制药顶点
- PSC 320/620G生物制药产品下游加工
- PSC 646G Regulatory Science
CBET劳动力发展与培训项目(2021年至今)
- Principles of Biomanufacturing
- 哺乳动物细胞培养:从细胞库到生物反应器
- NIIMBL eXperience at ACPHS
- FDA mRNA Training Program at ACPHS
- Modifications
Current Research Interests
Drug safety and efficacy, Cell-based screening platforms, Biopharmaceuticals, and Small-molecule drugs.
Medicines aim to prevent or treat diseases. 药物包括多种药物产品,包括生物制药和小分子药物. 生物制药是利用细胞系统生产的生物分子. Small-molecule drugs are synthesized chemically. 一种药物从发现到获得批准的过程是受到严格监管的. 最关键的问题包括这种药物是否安全有效. 我们的研究旨在探索药物作用的分子机制. Specifically, 我们采用基于细胞的筛选平台(2D和3D细胞培养系统)来检查化学物质和生物分子对细胞过程的影响, including cell growth, metabolism, migration, signaling, and gene expression. 此外,我们旨在探讨内在和外在因素对药品质量的影响. Through these combinatorial approaches, 本研究旨在加强对药物疗效和潜在毒性的分子机制的理解.
Additional Research Interests
- 了解工业相关细胞系统和新兴/备用底盘的生物学
- Engineering cells to produce value-added products
- 评估内在和外在因素如何影响产品质量和生产力
- Value-added Polysaccharides
- Monoclonal antibodies
Journal Review
- Biomolecules
- Biotechnology and Bioengineering
- Process Biochemistry
Book Chapter
- Industrial production of glycosaminoglycans. P. Datta, R. J. Linhardt, S. T. Sharfstein. In Encyclopedia of Microbiology http://www.sciencedirect.com/science/article/pii/B9780128096338122241
Review Articles
- 非动物来源的生物合成多糖类药物和营养品. P. Datta, R. J. Linhardt, Drug Target Review. 2020, 7:41-43 http://www.sciencedirect.com/science/article/pii/B9780128096338122241
- An ‘omics approach towards CHO cell engineering. P. Datta, R. J. Linhardt, S. T. Sharfstein. Biotechnology and Bioengineering. pubmed.ncbi.nlm.nih.gov/23322664/
Selected List of Publications
- 硝酸单基质硫酸鼠李糖抗sars - cov -2活性研究. Y. Song, P. He, A. L. Rodrigues, P. Datta, R. Tandon, J. T. Bates, M. Bierdeman, C. Chen, J. S. Dordick, F. Zhang, R. J. Linhardt, Marine Drugs. pubmed.ncbi.nlm.nih.gov/34940684/
- 利用表面等离子体共振评价肝素产品治疗肝素诱导的血小板减少症. F. Zhang, P. Datta, J. S. Dordick, R. J. Linhardt, Journal of Pharmaceutical Sciences. pubmed.ncbi.nlm.nih.gov/31705871/
- 血小板因子4多阴离子免疫复合物:肝素诱导的血小板减少症和疫苗诱导的免疫性血小板减少症. P. Datta, F. Zhang, J. S. Dordick, R. J. Linhardt, Thrombosis Journal. pubmed.ncbi.nlm.nih.gov/34526009/
- 硫酸软骨素在大肠杆菌中的完全生物合成. A. Badri, A. Williams, A. Awofiranye, P. Datta, K. Xia, W. He, K. Fraser, J. S. Dordick, R. J. Linhardt, M.A.G. Koffas, Nature Communication. nature.com/articles/s41467-021-21692-5
- 肝磷脂链表征:E. 由细菌消除酶肝素裂解酶III和细菌水解酶肝素酶Bp制备确定的低聚物. P. Datta, L. Yan, A. Awofiranye, J. S. Dordick, R. J. Linhardt, Biotechnology Journal. pubmed.ncbi.nlm.nih.gov/33006278/
- High cell density fermentation of probiotic E. 大肠杆菌Nissle 1917对肝素聚糖的生产,表征和修饰. P. Datta, L. Fu, P. Brodfuerer, J. S. Dordick, R. J. Linhardt, Applied Microbiology and Biotechnology. http://pubmed.ncbi.nlm.nih.gov/33481068/
- 酶法合成高抗凝血性牛肠肝素. L. Fu, K. Li, D. Mori, M. Hirakane, L. Lin, N. Grover, P. Datta, Y. Yu, J. Zhao, F. Zhang, M. Yalcin, S. Mousa, J. S. Dordick, R. J. Linhardt, Journal of Medicinal Chemistry. pubmed.ncbi.nlm.nih.gov/28972371/
- 3′-磷酸腺苷-5′-磷酸硫酸酯(PAPS)生物合成酶的表达及制备. P. Datta, L. Fu, W. He, M. A. G. Koffas, J. S. Dordick, R. J. Linhardt, Applied Microbiology and Biotechnology. http://pubmed.ncbi.nlm.nih.gov/32601738/
- 优化生物工艺条件提高了CHO细胞衍生产物的生产, bioengineered heparin. J. Y. Baik, H. Dahodwala, E. Oduah, L. Talman, T. R. Gemmill, L. Gasimli, P. Datta, B. Yang, G. Li, F. Zhang, L. Li, R. J. Linhardt, A. M. Campbell, S. F. Gorfien, S. T. Sharfstein, Biotechnology Journal. pubmed.ncbi.nlm.nih.gov/26037948/
- 微阵列平台为哺乳动物细胞生长研究提供了改进的产品分析. P. Datta, L. Meli, L. Li, N. Migliore, E. Schaefer, S. T. Sharfstein, J. S. Dordick, R. J. Linhardt, Biotechnology Journal. pubmed.ncbi.nlm.nih.gov/24227746/
- 丁酸钠对重组CHO细胞中硫酸肝素生物合成的调节作用. P. Datta, B. Yang, R. J. Linhardt, S. T. Sharfstein, Cytotechnology. http://pubmed.ncbi.nlm.nih.gov/24468831/
- 高尔基靶向3- o -硫转移酶-1生物工程中国仓鼠卵巢细胞合成硫酸肝素与抗凝血酶结合位点. P. Datta, G. Li, B. Yang, X. Zhao, J. Y. Baik, T. R. Gemmill, S. T. Sharfstein, R. J. Linhardt, Journal of Biological Chemistry. pubmed.ncbi.nlm.nih.gov/24247246/
- 肝素聚糖、硫酸肝素和肝素的微尺度分离. X. Zhao, B. Yang, K. Linkens, P. Datta, A. Onishi, F. Zhang, R. J. Linhardt, Analytical Biochemistry. pubmed.ncbi.nlm.nih.gov/23262074/
- 生物工程小鼠肥大细胞瘤细胞产生抗凝血肝素. L. Gasimli, C. A. Glass, P. Datta, B. Yang, G. Li, T. R. Gemmill, J. Y. Baik, S. T. Sharfstein, J. D. Esko, R. J. Linhardt, Glycobiology. pubmed.ncbi.nlm.nih.gov/24326668/
- 细胞微尺度分离糖胺聚糖用于糖组学研究. X. Zhao, B. Yang, P. Datta, L. Gasimli, F. Zhang, R. J. Linhardt, Journal of Carbohydrate Chemistry. pubmed.ncbi.nlm.nih.gov/24068855/
- 中国仓鼠卵巢细胞的代谢工程:一种生物工程肝素. J. Y. Baik, L. Gasimli, B. Yang, P. Datta, F. Zhang, C. A. Glass, J. D. Esko, R. J. Linhardt, S. T. Sharfstein, Metabolic engineering. pubmed.ncbi.nlm.nih.gov/22326251/
Selected Lists of Abstracts and Presentations
- 非蛋白生物制药生产的生物工艺优化:生物工程肝素的生产. S. T. Sharfstein, J. Y. Baik, L. Talman, E. Oduah, B. Yang, G. Li, F. Zhang, P. Datta, R. J. Linhardt. 第247届美国化学会全国会议暨博览会. 2014
- 哺乳动物细胞系肝素和硫酸肝素途径的细胞工程研究. P. Datta, B. Yang, L. Gasimli, J. Y.Baik, J. D. Esko, R. J. Linhardt, S. T. Sharfstein. 美国化学会全国会议,新奥尔良,洛杉矶. April 2013
- 生物组织和细胞中糖胺聚糖的双糖组成分析. B. Yang, A. Weyers, J. Y. Baik, S. T. Sharfstein, P. Datta, H. E. Stansfield, R. J. Linhardt. 第244届美国化学学会会议与博览会. 2012
- 生物工程肝素在哺乳动物细胞系中的合成. P. Datta, L. Gasimli, X. Zhao, B. Yang, J. Y. Baik, C. A. Glass, J. D. Esko, F. Zhang, S. T. Sharfstein, R. J. Linhardt. 第244届美国化学学会全国会议和博览会. 2012
- 细胞微尺度分离糖胺聚糖用于糖组学研究. X. Zhao, B. Yang, F. Zhang, P. Datta, L. Gasimli, R. J. Linhardt. 第243届美国化学会全国会议暨博览会. 2012